Which antibiotic is typically not used to treat uncomplicated urinary tract infections due to resistance concerns?

Amoxicillin is typically not used to treat uncomplicated urinary tract infections (UTIs) due to concerns about resistance. In many regions, the prevalence of resistance among uropathogens, particularly Escherichia coli, has increased significantly against amoxicillin and similar beta-lactam antibiotics. This makes it less effective as a first-line treatment for uncomplicated UTIs compared to alternatives like nitrofurantoin and sulfamethoxazole/trimethoprim, which still show higher efficacy in many cases. The choice of antibiotic depends largely on local resistance patterns and the specific characteristics of the patient’s infection; hence, awareness of resistance is vital in guiding treatment.